One-Step Electropolymerization of Azure A and Carbon Nanomaterials for DNA-Sensor Assembling and Doxorubicin Biosensing

New highly sensitive voltammetric DNA-sensors have been developed for the detection of cytostatic drug doxorubicin based on Azure A electropolymerized various carbon nanomaterials, i.e., functionalized multi-walled nanotubes (fMWCNTs) and black (CB). Carbon materials promote electropolymerization dye applied as a matrix DNA molecules saturated with methylene blue (MB) molecules. Interaction intercalator (doxorubicin) liberates MB changes redox activity. The concentration ranges reached by cyclic voltammetry were from 0.1 pM to 100 nM (limit detection, LOD, 0.03 pM) biosensor CB, 0.3 (LOD that fMWCNTs. tested spiked samples artificial serum, biological pharmaceutical samples. can find further application in monitoring residuals cancer treatment, well pharmacokinetics studies.